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– Multiple Phase 2 studies of allosteric TYK2 inhibitor in 2021 and 2022 will investigate ‘pipeline-in-a-product’ potential –

– Financing will also support first-in-human trial of HPK1 inhibitor and advancement of preclinical pipeline –

– Led by BVF Partners L.P., round included participation from new and existing investors –

CAMBRIDGE, Mass. – July 13, 2021 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced the closing of a $105 million private financing round. The round was led by BVF Partners L.P. (BVF), with participation from existing investors including RA Capital Management and Atlas Venture. Access Biotechnology, Commodore Capital, Logos Capital, Surveyor Capital (a Citadel company), and a large alternative asset manager joined as new investors in this financing.

“This financing from some of the world’s leading investors is validation of the exciting potential within Nimbus’ product pipeline and the singular expertise Nimbus brings in advancing these products forward.  Spurred by compelling data from studies of our novel allosteric TYK2 inhibitor, we will be embarking upon multiple Phase 2 clinical studies in 2021 and 2022 to elucidate the full range of potential patient benefit from this novel therapeutic,” said Jeb Keiper, M.S., MBA, Chief Executive Officer of Nimbus. “Our clinical expertise with this molecule to date combined with our strong capital position make Nimbus uniquely well-resourced to advance this important medicine through the clinic in the years to come.”

In addition to the Phase 2 studies of Nimbus’ allosteric TYK2 inhibitor, the financing will support a first-in-human study of the company’s HPK1 inhibitor candidate in cancer patients with solid tumors, which will begin later this year, and will accelerate preclinical programs against multiple targets in oncology and immunology. The company expects to initiate IND-enabling studies on two novel agents in 2022.

“Nimbus’ pipeline is positioned to deliver multiple clinical readouts over the next 18 months that have the promise to help transform patients’ lives,” said Bruce Booth, D.Phil., co-founder and Chairman of the Board of Nimbus. “We are fortunate to have the support of many new investors joining Nimbus, and we welcome Sam Huang from BVF to the Board.”

“We’re proud to lead this most recent financing round, and we see the tremendous potential of Nimbus’ vision, pipeline, and team,” said Mark Lampert, founder and CEO of BVF.

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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CAMBRIDGE, Mass. – May 10^th, 2021 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, announced it has appointed Anne McGeorge, M.S., CPA, to its Board of Directors, and as Audit Committee Chair. Ms. McGeorge is a seasoned finance executive with decades of experience advising healthcare and life sciences organizations.

“On behalf of Nimbus’ leadership team and Board, I am delighted to welcome Anne McGeorge to our Board of Directors. Anne’s technical acumen across all areas of finance for both private and public companies will be an asset to our business,” said Bruce Booth, Chairman of Nimbus. Jeb Keiper, Chief Executive Officer of Nimbus added, “As we expand our team and prepare to initiate clinical development of a second program, I am looking forward to partnering with Anne and the rest of the Board to continue to chart the future of Nimbus.”

Ms. McGeorge has more than 35 years of experience advising healthcare and life sciences businesses in areas of financial and strategic growth. She established and served as Managing Partner of Grant Thornton’s Global Health Care and Life Sciences Practices for more than a decade, and prior to that was a partner with both Deloitte and Arthur Andersen. Ms. McGeorge presently serves as Operating Partner at Havencrest Healthcare Partners and on the faculty of University of North Carolina’s School of Public Health. She serves as Board member and Audit Committee Chair for Magenta Therapeutics, SOC Telemed, and CitiusTech, and as Board Chair for Be The Match Foundation. Ms. McGeorge holds a BBA in business administration and accounting from The College of William & Mary and an M.S. in accounting from the University of Virginia.

“Nimbus’ trajectory in recent years has been very exciting to watch, and I’m pleased to be joining the company at such an important stage,” said McGeorge. “Building on the company’s longstanding expertise in drug discovery, Nimbus is now a clinical-stage biotech with wide development capabilities and aspirations, and an unmatched team in place. I’m looking forward to helping shape this great potential for the benefit of Nimbus’ investors and patients.” 

About Nimbus Therapeutics 

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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– Key hires in clinical and CMC augment Nimbus’ in-house capabilities as a development-stage biotech –

CAMBRIDGE, Mass. – April 21, 2021 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, announced the expansion of its development team with the appointment of accomplished professionals in three key development positions: Avinash Phadke, Ph.D., joins Nimbus as Vice President of CMC; Bhaskar Srivastava, M.D., Ph.D., joins as Vice President of Early Clinical Development; and Ajay K. Upadhyay joins as Vice President of Clinical Operations.

“We have begun assembling a world-class development team here at Nimbus. The appointments of Avinash, Bhaskar, and Ajay are central to our growing development capabilities, and enable Nimbus to progress its advancing portfolio through clinical investigation in multiple indications and disease settings,” said Annie C. Chen, M.D., MPH, Nimbus’ Chief Medical Officer and President of Nimbus’ TYK2 subsidiary. “In the near term, in addition to advancing our allosteric tyrosine kinase 2 (TYK2) inhibitor toward Phase 2 testing, we also plan to initiate clinical testing for our highly selective and potent hematopoietic progenitor kinase 1 (HPK1) inhibitor later this year. Nimbus’ deepened development focus, alongside our well-known prowess in small molecule drug discovery, position us to grow and diversify our pipeline in exciting ways in the years to come.”

Dr. Phadke, Nimbus’ Vice President of CMC, joins from Achillion Pharmaceuticals where he held numerous roles of increasing responsibility in chemistry and CMC over his 18-year tenure, most recently as Vice President, Head of CMC. In that role Dr. Phadke developed manufacturing processes for and oversaw the manufacturing of eight small molecule investigational therapeutics across all stages of clinical development scale-up. Dr. Phadke holds a Ph.D. in organic chemistry and B.Sc. in chemistry from Savitribai Phule Pune University and an M.S. in chemistry from the Indian Institute of Technology.

Dr. Srivastava, Nimbus’ Vice President of Early Clinical Development, served most recently as Senior Director, Early Development Translational Science and Medicine in Immunology at the Janssen Pharmaceutical Companies of Johnson & Johnson. In that role he led a team responsible for strategy, design, and execution of early-phase clinical immunology programs. Dr. Srivastava’s previous roles at Janssen included Director of Early Development and Translational Medicine, Immunology, and Director of Medical Affairs in Dermatology. Prior to Janssen, Dr. Srivastava was a practicing dermatologist. He holds an A.B. in biochemical sciences from Harvard University and an M.D. and Ph.D. in immunology from the University of Pennsylvania School of Medicine.

Mr. Upadhyay, Nimbus’ Vice President of Clinical Operations, has held numerous positions across drug development, most recently as president of the consulting firm October Global Solutions Inc. Previously, Mr. Upadhyay served in the Medical Affairs, Americas leadership team at Astellas Pharma, first in the role of Senior Director of Clinical Studies and later as Executive Director of Clinical/Outcomes Sciences. Before Astellas, Mr. Upadhyay was at GlaxoSmithKline for nine years, where he held roles of ascending responsibility in the Oncology R&D Unit and oversaw teams managing the operational implementation of regional and global clinical trials in development and medical affairs across the portfolio. Mr. Upadhyay holds a B.S. in pharmacology and toxicology from Philadelphia College of Pharmacy and an M.S. in Quality Assurance/Regulatory Affairs from Temple University.

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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CAMBRIDGE, Mass. – April 9, 2021 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced the presentation of data from the company’s HPK1 inhibitor program in a poster at the AACR Annual Meeting held virtually April 10-15, 2021.

Newly disclosed data show that Nimbus’ small-molecule HPK1 inhibitor, NMBS-2, demonstrates significant tumor growth inhibition as a single agent and in combination with anti-PD1 in multiple mouse syngeneic tumor models. In combination with anti-PD1, NMBS-2 restored cytokine secretion from exhausted human T cells and induced robust tumor growth inhibition in the CT-26 model. Furthermore, animals treated with NMBS-2 and anti-PD1 showed complete rejection of subsequently reintroduced CT-26 tumor cells, suggesting the establishment of a robust and durable immune memory.

“Building on our promising findings to date demonstrating the anti-tumor immune activity of NMBS-2, these latest data provide a compelling picture of its potential clinical utility in a range of tumor types — both as a single agent and as a combination therapy with anti-PD1 treatment,” said Peter Tummino, Ph.D., Chief Scientific Officer of Nimbus. “We’re rapidly progressing IND-enabling studies of NMBS-2 now with plans to initiate first-in-human studies in the second half of 2021.” 

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com

Media Contact

Lisa Raffensperger, (617) 903-8783
Ten Bridge Communications
lisa@tenbridgecommunications.com

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– Supported by positive preclinical data, Nimbus will pursue IND submission for HPK1 inhibitor candidate in 2021 –

CAMBRIDGE, Mass. – Dec. 30, 2020 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced that it has regained the worldwide rights to its HPK1 inhibitor program from Bristol Myers Squibb. Under Nimbus’ agreement with Celgene, now a Bristol Myers Squibb company, Celgene held an option to acquire the HPK1 inhibitor program. As part of its Celgene integration process, Bristol Myers Squibb is streamlining and prioritizing its portfolio and as a result, made the decision to decline this option.

“We’re excited to continue progressing our small molecule HPK1 inhibitors within Nimbus’ wholly owned pipeline. Preclinical data we presented this year at prominent oncology conferences show that our potent HPK1 inhibitor has a high degree of selectivity, demonstrates in vitro effects on T cells, B cells and dendritic cells, and shows significant in vivo tumor growth inhibition across multiple animal models,” said Peter Tummino, Ph.D., Chief Scientific Officer of Nimbus. “We look forward to progressing this promising immuno-oncology program into a first-in-human clinical study in 2021.”

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com

Media Contact

Lisa Raffensperger, (617) 903-8783
Ten Bridge Communications
lisa@tenbridgecommunications.com

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CAMBRIDGE, Mass. – Nov. 5, 2020 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, will host its second in a series of virtual seminars highlighting the latest data from its HPK1 program. The seminar, titled “Novel, Potent, Selective HPK1 Inhibitors Enhance Immune Activation to Inhibit Tumor Growth,” will take place on Tuesday, Nov. 17, from 11 a.m. to 12 p.m. ET.

Nimbus’ scientific leadership will present new preclinical data on the anti-tumor immune activity of its small-molecule HPK1 inhibitors. These data are featured in recent poster presentations at the EORTC-NCI-AACR Symposium and the upcoming Society for Immunotherapy of Cancer (SITC) Annual Meeting.

If you wish to attend the live seminar, please pre-register at: Nimbus HPK1 Seminar II. A replay of the webcast will be available at this link after the event.

A recording of Nimbus’ previous HPK1 seminar can be accessed at https://bit.ly/NimbusHPK1Seminar

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com

Media Contact

Lisa Raffensperger, (617) 903-8783
Ten Bridge Communications
lisa@tenbridgecommunications.com

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CAMBRIDGE, Mass. – October 22, 2020 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced the presentation of new data on the company’s novel hematopoietic progenitor kinase 1 (HPK1) inhibitors at upcoming scientific conferences.

At the 32^nd EORTC-NCI-AACR Symposium, from October 24-25, 2020, Nimbus will present new in vivo data, including target engagement, tumor growth inhibition, and pharmacodynamics in two mouse syngeneic tumor models (CT26 and B16/F10).

Further, at the Society for Immunotherapy of Cancer’s (SITC) 35^th Anniversary Annual Meeting, from November 9-14, 2020, Nimbus will present new data on in vitro pharmacology and mechanism of action of the HPK1 inhibitors, including effects on T cells, B cells, dendritic cells and antigen presentation.

“Building on the data we presented at AACR earlier this year, we’re pleased to share these new results which provide further support for the anti-tumor immune activity of our small-molecule HPK1 inhibitors,” said Peter Tummino, Ph.D., Chief Scientific Officer of Nimbus. “We are progressing towards initiation of IND-enabling studies in the near future, with plans to embark upon first-in-human studies of this novel therapeutic in 2021.”

Details of the presentations are as follows:

EORTC 2020: Pre-recorded presentation with live Q&A

• Title: “A Highly Selective and Potent HPK1 Inhibitor Enhances Immune Cell Activation and Induces Robust Tumor Growth Inhibition in a Murine Syngeneic Tumor Model”
• Presentation Number: PD-046
• Date & Time: Sun., Oct. 25, 2:50 p.m. CET (9:50 a.m. ET)

SITC 2020: Live presentation

• Title: “A Highly Selective and Potent HPK1 Inhibitor Enhances Immune Cell Activation and Induces Robust Tumor Growth Inhibition in a Murine Syngeneic Tumor Model”
• Poster Number: 685
• Dates & Times: Weds., Nov. 11, 5:15 p.m. ET; Fri., Nov. 13, 4:40 p.m. ET

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com.

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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CAMBRIDGE, Mass. – October 19, 2020 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced the appointment of Erin Cowhig as Chief People Officer. In this newly created role, Ms. Cowhig will oversee all aspects of Nimbus’ human resources, talent acquisition and management, and diversity and inclusion efforts.

“Our people are the reason for Nimbus’ many years of success. With Erin’s leadership as Chief People Officer we are excited to further build our high-performing team, continuing to recruit talented and diverse new Nimbi, develop and invest in our people, and foster a values-driven culture,” said Jeb Keiper, M.S., MBA, Chief Executive Officer of Nimbus. “We’re very excited to welcome Erin to the Nimbus team and are confident that her deep experience in human resources, talent acquisition, and diversity and inclusion will contribute to driving Nimbus’ future success.”

Prior to joining Nimbus, Ms. Cowhig was Vice President, Human Resources at Vertex Pharmaceuticals, where she was responsible for HR governance, portfolio management, and organizational effectiveness as well as serving on Vertex’s HR leadership team. Ms. Cowhig was also responsible for leading Vertex’s Diversity and Inclusion strategy. Prior to Vertex, Ms. Cowhig was Senior Director and Head of Talent at Agios Pharmaceuticals, where she led talent acquisition and talent management efforts amidst the company’s transition from a research-focused organization to a late-stage development and commercial company. Ms. Cowhig holds a B.S. in human development and a Master of Industrial and Labor Relations, both from Cornell University.

“Nimbus’ community of passionate, talented people is an incredible asset, and it’s a team I feel privileged to join,” said Ms. Cowhig. “I’m excited to build upon the people-centric culture Nimbus has created to continue to make Nimbus a place of diverse, engaged, top-notch people who are empowered to do their best work and to make a difference in the lives of patients.”

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com.

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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Leading life science investors RA Capital Management and BVF Partners L.P. join Nimbus investor base

CAMBRIDGE, Mass. – October 14, 2020 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced the close of a $60 million private financing round from life science investors RA Capital Management and BVF Partners L.P. (“RA” and “BVF”, respectively). The funds support the acceleration of Nimbus’ Phase 1 allosteric tyrosine kinase 2 (TYK2) inhibitor into Phase 2 early next year, its hematopoietic progenitor kinase 1 (HPK1) inhibitor into the clinic next year, as well as the advancement of its preclinical portfolio of new medicines.

“Today’s financing evidences the remarkable success of our structure-based drug discovery approach and the exciting data our pipeline has generated,” said Jeb Keiper, M.S., MBA, Chief Executive Officer of Nimbus. “This financing also defines a pathway for our future, and while we could not welcome all the investors with interest in Nimbus into this round, we expect with continued success to build on this financing by bringing on additional new investment in 2021.”

“Nimbus’ compelling TYK2 clinical data clearly positions us for a Phase 2b trial, which will generate data on the same endpoints as BMS’ TYK2 program,” said Bruce Booth, D.Phil., co-founder and Chairman of the Board of Nimbus. “We are fortunate to have RA and BVF join Nimbus, and we welcome Laura Stoppel from RA to the Board.”

“We’re proud to join Nimbus’ circle of investors and to lead this most recent financing round,” said Peter Kolchinsky, Ph.D., a founder and Managing Partner of RA Capital Management. “We see tremendous potential for Nimbus’ lead program, one of only two clinical allosteric approaches to TYK2 inhibition, and for the company’s newly added preclinical programs to address important therapeutic needs in oncology, immunology, and metabolism.”

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com.

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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CAMBRIDGE, Mass. – September 28, 2020 – Nimbus Therapeutics, a biotechnology company designing breakthrough medicines through structure-based drug discovery and development, today announced the promotion of Abbas Kazimi to Chief Business Officer. Mr. Kazimi, who previously served as Vice President of Business Development, has more than 15 years of experience directing strategic transactions within the life sciences industry.

“Throughout his tenure with Nimbus, Abbas has played a central role in building our external partnerships, negotiating key transactions, and shaping our corporate strategy. We are exceptionally pleased to promote him to the role of Chief Business Officer,” said Jeb Keiper, M.S., MBA, Chief Executive Officer of Nimbus. “Abbas’ deep acumen in business and corporate development will be an asset for Nimbus as he moves into this expanded leadership role, and I look forward to continuing to partner with him to drive Nimbus’ success.”

Mr. Kazimi joined Nimbus in 2014 as Director of Business Development. In his roles at Nimbus, Mr. Kazimi drove several of the company’s transformative transactions, including the licensing agreement with Genentech in 2015, the sale of Nimbus’ clinical NASH program to Gilead up to an aggregate of $1.2 billion in 2016, and the strategic alliances with Celgene announced in 2017 and 2019. Prior to joining Nimbus, Mr. Kazimi spent a decade in planning and executing strategic transactions for life sciences clients with industry partners and financial investors across the globe. He earned his M.A. from Harvard University and his B.A. from the University of Texas at Austin.

About Nimbus Therapeutics

Nimbus Therapeutics designs breakthrough medicines. Utilizing its powerful structure-based drug discovery engine, Nimbus designs potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. The company’s LLC/subsidiary architecture enables diverse and synergistic partnerships to deliver breakthrough medicines. Nimbus is headquartered in Cambridge, Mass. www.nimbustx.com.

Media Contact

Lisa Raffensperger, (617) 903-8783

Ten Bridge Communications

lisa@tenbridgecommunications.com

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